Exosomes

Role of extracellular matrix in cancer


BIOGRAPHY - LAHIRU GANGODA

 

Lahiru Gangoda completed her undergraduate degree with First class Honours (Majoring in Biochemistry and Molecular Biology) from University of Colombo, Sri Lanka in 2005. In 2008 she obtained a Masters in Biotechnology and Bioinformatics from La Trobe University. Her Masters Research project "Development of a genetically encoded cytochemical probe for different compartments of mammalian cells for fluorescence and electron microscopy applications" was supervised by Prof. Leann Tilley.

 

Following her Master degree, she joined the lab of Prof. Nicholas Hoogenraad as a full time Research Assistant during which she gained skills in monoclonal antibody production and screening.

 

In 2011 she started her doctoral studies under the supervision of Dr. Hamsa Puthalakath. Her PhD research was based on mouse tumor models and investigated the role of Bim as a tumor suppressor in Carney complex.

 

She joined Dr. Suresh Mathivanan lab in 2014 and her current research focus is on overcoming chemotherapeutic drug resistance in colorectal cancer.



PUBLICATIONS

 


2016

14. Gangoda, L. and Mathivanan, S. (2016) Cortactin enhances exosome secretion without altering cargo. Journal of Cell Biology. 214 (2): 129.

 

13. Cheung, KH., Keerthikumar, S., Roncaglia, P., Subramanian, SL., Roth, ME., Samuel, M., Anand, S., Gangoda, L., Gould, S., Alexander, R., Galas, D., Gerstein, MB., Hill, AF., Kitchen, RR., Lotvall, J., Patel, T., Procaccini, DC., Queensberry, P., Rozowsky, J., Raffai, RL., Shypitsyn, A., Su, AI., Thery, C., Vickers, K., Wauben, M., Mathivanan, S., Milosavljevic, A. and Laurent, L. (2016). Extending Gene Ontology in the Context of Extracellular RNA and Vesicle Communication. Journal of Biomedical Semantics. 7:19.

 

12. Chisanga, D., Keerthikumar, S., Pathan, M., Ariyaratne, D., Kalra, H., Boukouris, S., Mathew, N., Al Saffar, H., Gangoda, L., Ang, C.S., Sieber, O., Mariadason, J., Dasgupta, R., Chilamkurti, N. and Mathivanan, S. (2016) Colorectal Cancer Atlas: An integrative resource for genomic and proteomic annotations from colorectal cancer cell lines and tissue. Nucleic Acids Research.(IF:9.1). 44(D1), D969-74.

 

11. Keerthikumar, S., Chisanga, D., Ariyaratne, D., Al Saffar, H., Anand, S., Zhao, S., Samuel, M., Pathan, M., Jois, M., Chilamkurti, N., Gangoda, L. and Mathivanan, S*. (2016). ExoCarta: A web-based compendium of exosomal cargo. Journal of Molecular Biology. 428(4), 688-92.(IF:4.3).

 



2015

10. Pathan, M., Keerthikumar, S., Ang, C.S., Gangoda, L., Quek, C.M.J., Williamson, N.J., Mouradov, D., Sieber, O.M., Simpson, R.J., Salim, A., Bacic, A., Hill, A.F., Stroud, D.A., Ryan, M.T., Agbinya, J.A., Mariadasson, J.M., Burgess, A.W. and Mathivanan, S. FunRich: a standalone tool for functional enrichment analysis. Proteomics. 15, 2597-2601.(IF:3.9).



9. Keerthikumar, S.,# Gangoda, L.,#  Liem, M., Fonseka, P., Atukorala, I., Ozcitti, C., Shambrook, M.C., Scicluna, B.J., Hill, A.F., Mechler, A., Adda, C.G.,  Ang, C.S. and Mathivanan, S. Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes. Oncotarget. (2015).6:17, 15375-15396. (IF:6.6).

# Equal contribution



8. Gangoda, L., Keerthikumar, S., Fonseka, P., Edgington, L.E., Ang, C.S., Ozcitti, C., Bogyo, M., Parker, B.S. and Mathivanan, S.  Inhibition of cathepsin proteases attenuates migration and sensitizes aggressive N-Myc amplified human neuroblastoma cells to doxorubicin. Oncotarget. (2015).6:13, 11175-11190. (IF:6.6).

7. Gangoda, L., Boukouris, S., Liem, M., Kalra, H. and Mathivanan, S. Extracellular vesicles including exosomes are mediators of signal transduction: Are they protective or pathogenic? Proteomics. (2014). 15: 2-3, 260-71. (IF:4).

 



2014

6. Rickard, J. A., Anderton, H., Etemadi, N., Nachbur, U., Darding, M., Peltzer, N., Lalaoui, N., Lawlor, K. E., Vanyai, H., Hall, C., Bankovacki, A., Gangoda, L., Wong, W. W., Corbin, J., Huang, C., Mocarski, E. S., Murphy, J. M., Alexander, W. S., Voss, A. K.,Vaux, D. L., Kaiser, W. J., Walczak, H. and Silke, J. TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice. eLife. (2014) 3. (IF: 8.5).

 

5. Gangoda, L., Doerflinger, M., Edgington, L.E., Orian, J., Hawkins, C., O'Reilly. L.A., Gu, H., Bogyo, M., Ekert, P., Strasser, A. and Puthalakath, H. Loss of PRKAR1A leads to Bcl-2 family protein induction and cachexia in mice. Cell Death Differ (2014).21:11, 1815-24.(IF:8.4).

 



2013

4. Lee, Y. Y., Moujalled, D., Doerflinger, M., Gangoda, L., Weston, R., Rahimi, A., de Alboran, I., Herold, M., Bouillet, P., Xu, Q., Gao, X., Du, X. J., Puthalakath, H. CREB-binding protein (CBP) regulates beta-adrenoceptor (beta-AR)-mediated apoptosis. Cell Death Differ (2013) 20 7 941-52 (IF:8.4)

 

3. Rahimi, A., Lee, Y. Y., Abdella, H., Doerflinger, M., Gangoda, L., Srivastava, R., Xiao, K., Ekert, P. G., Puthalakath, H. Role of p53 in cAMP/PKA pathway mediated apoptosis. Apoptosis (2013) 18 12 1492-9 (IF:4)

 



2012

2. Gangoda, L., Doerflinger, M., Lee, Y. Y., Rahimi, A., Etemadi, N., Chau, D., Milla, L., O'Connor, L., Puthalakath, H. Cre transgene results in global attenuation of the cAMP/PKA pathway. Cell Death Dis (2012) 3 e365 (IF:6)

 



2011

1. Gerlach, B., Cordier, S. M., Schmukle, A. C., Emmerich, C. H., Rieser, E., Haas, T. L., Webb, A. I., Rickard, J. A., Anderton, H., Wong, W. W., Nachbur, U., Gangoda, L., Warnken, U., Purcell, A. W., Silke, J., Walczak, H. Linear ubiquitination prevents inflammation and regulates immune signalling. Nature (2011) 471 7340 591-6 (IF:38.6)