Exosomes

Role of extracellular matrix in cancer


BIOGRAPHY - SURESH MATHIVANAN

 

Professor Suresh Mathivanan undertook a PhD in proteomics and bioinformatics at the Institute of Bioinformatics, India and Johns Hopkins University, USA. After PhD, Suresh joined Ludwig Institute for Cancer Research, Melbourne, Australia as a postdoctoral researcher.

In 2011, he received a NH&MRC Peter Doherty fellowship to study exosomes secreted by cancer cells. Further to this, in 2015 and 2018, he received an ARC DECRA and ARC Future Fellowship to study the role of exosomes in intercellular communication.

Suresh moved to the Department of Biochemistry, La Trobe Institute for Molecular Science (LIMS) at La Trobe University after receiving a LIMS fellowship to set up his own research group in 2011. At LIMS, Mathivanan's laboratory is focused on exosomes, their role in cancer and intercellular communication.

He has authored over 126 articles that are cited more than 41,270 times (Google Scholar). He has been listed as a 'Highly Cited Researcher' by Web of Science from 2018-2023.




Academic Qualifications

2009 Ph.D. Biotechnology, Johns Hopkins University, Baltimore, MD, USA, and Kuvempu University, Karnataka, India



Awards

2023 Highly Cited Researcher for 2023, Web of Science
2022 Highly Cited Researcher for 2022, Web of Science
2021 Highly Cited Researcher for 2021, Web of Science
2020 Highly Cited Researcher for 2020, Web of Science
2019 Highly Cited Researcher for 2019, Web of Science
2019 Leading researcher in the field of proteomics, peptides and amino acids, The Australian
2018 Highly Cited Researcher for 2018, Web of Science
2018 ARC Future Fellowship (FT2) (2018-2022)
2017 Research Excellence Award, La Trobe University
2015 Victorian Tall Poppy Award
2015 ARC DECRA (2015-2017)
2014 The Eppendorf Edman Award, ASBMB
2014 The Bioplatforms Australia Award, ASBMB
2014 Ken Mitchellhill Young Investigator Award, Australian Proteomics Society
2014 Ramaciotti Establishment Award
2013 Scopus Young Researcher Award (Finalist)
2013 Science Pathways Forum Award, La Trobe University
2011 NHMRC post-doctoral Training Fellowship (2011-2014)
2011 Young Investigator Award, 16th Proteomics Symposium, Australia
2011 Deans Award for Excellence in Research, La Trobe University
2010 Australian Proteomics Society Travel grant
2004 Fellowship from the Department of Biotechnology, India



Professional Activities

Editorial board member: International Journal of Cancer
Editorial board member: Proteomes



SELECTED PUBLICATIONS

 


1. Samuel, M., Fonseka, P., Sanwlani, R., Gangoda, L., Chee, S.H., Keerthikumar, S., Spurling, A., Chitti, S.V., Zanker, D., Ang, C.S., Atukorala, I., Kang, T., Shahi, S., Marzan, A.L., Nedeva, C., Vennin, C., Lucas, M.C., Cheng, L., Herrmann, D., Pathan, M., Chisanga, D., Warren, S.C., Zhao, K., Abraham, N., Anand, S., Boukouris, S., Adda, C.G., Jiang, L., Shekhar, T.M., Baschuk, N., Hawkins, C.J., Johnston, A.J., Orian, J.M., Hoogenraad, N.J., Poon, I.K., Hill, A.F., Jois, M., Timpson, P., Parker, B.S. and Mathivanan, S. (2021) Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis. Nature Communications. 3950.

2. Kalra, H., Gangoda, L., Fonseka, P., Chitti, S.V., Liem, M., Keerthikumar, S., Samuel, M., Boukouris, S., Al Saffar, H., Collins, C., Adda, C.G., Ang, C.S. and Mathivanan, S. (2019) Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signaling pathway in the recipient cells. Journal of Extracellular Vesicles. 8:1690217.

3. Zhao, K., Bleackley, M., Chisanga, D., Gangoda, L., Fonseka, P., Liem, M., Kalra, H., Al Saffar, H., Keerthikumar, S., Ang, C.S., Adda, C., Jiang, L., Yap, K., Poon, I., Lock, P., Bulone, P., Anderson, M*. and Mathivanan, S*. (2019) Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling. Communications Biology. 2:305.
* - Equal contribution

4. Fonseka, P., Liem, M., Ozcitti, C., Adda, C.G., Ang, C.S. and Mathivanan, S. (2019) Exosomes from N-Myc amplified neuroblastoma cells induce migration and confer chemoresistance to non-N-Myc amplified cells: implications of intra-tumor heterogeneity. Journal of Extracellular Vesicles. 8:1597614.

5. Pathan, M*., Fonseka, P*., Chitti, S.V., Kang, T., Sanwlani, R., Van Deun, J., Hendrix, A. and Mathivanan, S. (2019) Vesiclepedia 2019: a compendium of RNA, proteins, lipids and metabolites in extracellular vesicles. Nucleic Acids Research. D516-D519.
* - Equal contribution

6. Chisanga, D., Keerthikumar, S., Pathan, M., Ariyaratne, D., Kalra, H., Boukouris, S., Mathew, N., Al Saffar, H., Gangoda, L., Ang, C.S., Sieber, O., Mariadason, J., Dasgupta, R., Chilamkurti, N. and Mathivanan, S. (2016) Colorectal Cancer Atlas: An integrative resource for genomic and proteomic annotations from colorectal cancer cell lines and tissue. Nucleic Acids Research. 44(D1), D969-74.

7. Kalra, H., Simpson, R.J., Ji, H., Aikawa, E., Altevogt, P., Askenase, P., Bond, V.C., Borras, F.E., Breakefield, X., Budnik, V., Buzas, E., Camussi, G., Clayton, A., Cocucci, E., Falcon-Perez, J.M., Gabrielsson, S., Gho, Y.S., Gupta, D., Harsha, H.C., Hendrix, A., Hill, A.F., Inaal, J.M., Jenster, G., Kiang, L.S., Kramer-Albers, E-M., Llorente, A., Lotvall, J., Mincheva-Nilsson, L., Nazarenko, I., Nieuwland, R., Nolte-'t Hoen, E.N.M., Pandey, A., Patel, T., Piper, M.G., Pluchino, S., Prasad, T.S.K., Rajendran, L., Raposo, G., Record, M., Reid, G.E., Sanchez-Madrid, F., Schiffelers, R.M., Siljander, P., Stoorvogel, W., Taylor, D., Thery, C., Valadi, H., van Balkom, B.W.M., Vazquez, J., Vidal, M., Yanez-Mo, M., Zoeller, M. and Mathivanan, S. (2012) Vesiclepedia: A compendium for extracellular vesicles with continuous community annotation. PLoS Biology. 12, e1001450.

8. Mathivanan, S., Ahmed, M. et al. (2008). Human Proteinpedia enables sharing of human protein data. Nature Biotechnology. 26, 164-7.

9. Amanchy, R., Periaswamy, B., Mathivanan, S., Reddy, R., Tattikota, S. G. and Pandey, A. (2007). A compendium of curated phosphorylation-based substrate and binding motifs. Nature Biotechnology. 25, 285-286.

10. Gandhi, T. K. B., Zhong, J., Mathivanan, S., Karthick, L., Chandrika, K. N., Mohan, S. S., Sharma, S., Pinkert, S., Nagaraju, S., Periaswamy, B., Mishra, G., Nandakumar, K., Shen, B., Deshpande, N., Nayak, R., Sarker, M., Boeke, J. D., Parmigiani, G., Schultz, J., Bader, J. S. and Pandey, A. (2006). Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets. Nature Genetics. 3, 285-293.